Dataset Information

Dataset on the small- and large deformation mechanical properties of emulsion-filled gelatin hydrogels as a model particle-filled composite food gel.

ABSTRACT: In this article we present data related to the original research articles 'Effect of matrix architecture on the elastic behavior of an emulsion-filled polymer gel' (Gravelle et al., 2021) and 'The influence of network architecture on the large deformation and fracture behavior of emulsion-filled gelatin gels' (Gravelle and Marangoni, 2021). The small deformation elastic (Young's) modulus and large deformation fracture behavior of emulsion-filled composite gelatin gels are reported as a function of filler volume fraction (ϕ_f = 0 - 0.32). Homogeneous and heterogeneous network architectures were achieved by varying electrostatic interactions between matrix and filler. The effect of emulsion droplet physical state (solid fat or liquid oil) and gelator concentration (2, 4, 6, or 8% gelatin) were also evaluated. The reported elastic modulus, and fracture properties were obtained from large deformation uniaxial compression tests. Power law scaling behavior was identified for the elastic modulus as a function of both ϕ_f and gelator concentration, which are also reported. This data is relevant to the evaluation of network properties on the applicability of small deformation particle reinforcement theories and models describing the fracture mechanics of filled composites such as fat-filled food systems.

SUBMITTER: Gravelle AJ

PROVIDER: S-EPMC8479625 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundTissue engineering, which involves the selection of scaffold materials, presents a new therapeutic strategy for damaged tissues or organs. Scaffold design based on blends of proteins and polysaccharides, as mimicry of the native extracellular matrix, has recently become a valuable strategy for tissue engineering.ObjectiveThis study aimed to construct composite hydrogels based on natural polymers for tissue engineering.MethodsComposite hydrogels based on blends of gelatin with a polysaccharide component (chitosan or alginate) were produced and subsequently enzyme crosslinked. The other three hydrogels, chitosan hydrogel, sodium alginate hydrogel, and microbial transglutaminase-crosslinked gelatin (mTG/GA) hydrogel were also prepared. All hydrogels were evaluated for in vitro degradation property, swelling capacity, and mechanical property. Rat adipose-derived stromal stem cells (ADSCs) were isolated and seeded on (or embedded into) the above-mentioned hydrogels. The morphological features of ADSCs were observed and recorded. The effects of the hydrogels on ADSC survival and adhesion were investigated by immunofluorescence staining. Cell proliferation was tested by thiazolyl blue tetrazolium bromide (MTT) assay.ResultsCell viability assay results showed that the five hydrogels are not cytotoxic. The mTG/GA and its composite hydrogels showed higher compressive moduli than the single-component chitosan and alginate hydrogels. MTT assay results showed that ADSCs proliferated better on the composite hydrogels than on the chitosan and alginate hydrogels. Light microscope observation and cell cytoskeleton staining showed that hydrogel strength had obvious effects on cell growth and adhesion. The ADSCs seeded on chitosan and alginate hydrogels plunged into the hydrogels and could not stretch out due to the low strength of the hydrogel, whereas cells seeded on composite hydrogels with higher elastic modulus, could spread out, and grew in size.ConclusionThe gelatin-polysaccharide composite hydrogels could serve as attractive biomaterials for tissue engineering due to their easy preparation and favorable biophysical properties.

Dataset Information

Dataset on the small- and large deformation mechanical properties of emulsion-filled gelatin hydrogels as a model particle-filled composite food gel.

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