Ontology highlight
ABSTRACT:
SUBMITTER: Sun B
PROVIDER: S-EPMC8479697 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Sun Bingzhi B Li Gaojie G Guo Ling L Yin Na N Huang Huan H Wu Xiaodong X Huang Runyue R Feng Min M
iScience 20210910 10
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that would permanently damage the affected joints. Unfortunately, a large proportion of RA patients fail to respond adequately to current treatments. Here, repurposing hemin and its ultra-long-acting formulation were explored for the effective treatment of RA in animal models. We provided evidence that hemin prevented the onset and ameliorated the clinical course of RA. Notably, hemin treatment rescued the dysregulated gene expressi ...[more]