Persistent HIV-1 transcription in CD4⁺ T cells from ART-suppressed individuals can originate from biologically competent proviruses.

ABSTRACT: HIV-1 is able to persist in the face of potent antiretroviral therapy (ART). A number of strategies are being explored to allow ART-free viral remission or viral eradication. In order to gauge the progress of these strategies, assays with which to measure viral reservoir size and activity are needed. In a large percentage of aviremic individuals on suppressive ART, viral transcripts can be detected in peripheral blood CD4⁺ T cells. While this cell-associated RNA has been considered as a marker of viral reservoir activity, it is unclear whether cell-associated viral transcripts in aviremic individuals originate from biologically competent proviruses as opposed to being a product of abortive transcription from defective proviruses. We assessed whether cell-associated viral RNA in

SUBMITTER: Vignoles M 

PROVIDER: S-EPMC8479831 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature