Last-line local treatment with the Quad Shot regimen for previously irradiated head and neck cancers.

ABSTRACT:

Objectives

Patients with prior irradiated head and neck cancer (HNC) who are ineligible for definitive retreatment have limited local palliative options. We report the largest series of the use of the Quad Shot (QS) regimen as a last-line local palliative therapy.

Materials and methods

We identified 166 patients with prior HN radiation therapy (RT) treated with QS regimen (3.7 Gy twice daily over 2 consecutive days at 4 weeks intervals per cycle, up to 4 cycles). Palliative response defined by symptom(s) relief or radiographic tumor reduction, locoregional progression free survival (LPFS), overall survival (OS) and radiation-related toxicity were assessed.

Results

Median age was 66 years. Median follow-up for all patients was 6.0 months and 9.7 months for living patie

SUBMITTER: Fan D 

PROVIDER: S-EPMC8480112 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature