Drinking Water Disinfection by-Products and Congenital Malformations: A Nationwide Register-Based Prospective Study.

ABSTRACT:

Background

Drinking water chlorination by-products have been associated with adverse reproductive outcomes, although the findings for congenital malformations are still inconclusive.

Objective

We conducted a nationwide register-based prospective study to assess whether first trimester maternal exposure to the four most common trihalomethanes [total trihalomethanes (TTHM)] via municipal drinking water was associated with risk of congenital malformation among newborns.

Methods

We included all births during 2005-2015 (live and stillbirths) of mothers residing in Swedish localities having >10,000 inhabitants, two or fewer operating water works, and sufficient municipal TTHM monitoring data. Individual maternal first trimester exposure was obtained by linking TTHM measurem

SUBMITTER: Save-Soderbergh M 

PROVIDER: S-EPMC8480150 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature