Molecular mechanisms of activation and regulation of ANO1-Encoded Ca²⁺-Activated Cl^- channels.

ABSTRACT: Ca²⁺-activated Cl^- channels (CaCCs) perform a multitude of functions including the control of cell excitability, regulation of cell volume and ionic homeostasis, exocrine and endocrine secretion, fertilization, amplification of olfactory sensory function, and control of smooth muscle cell contractility. CaCCs are the translated products of two members (ANO1 and ANO2, also known as TMEM16A and TMEM16B) of the Anoctamin family of genes comprising ten paralogs. This review focuses on recent progress in understanding the molecular mechanisms involved in the regulation of ANO1 by cytoplasmic Ca²⁺, post-translational modifications, and how the channel protein interacts with membrane lipids and protein partners. After first reviewing the basic properties of native

SUBMITTER: Hawn MB 

PROVIDER: S-EPMC8480199 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature