Antibody persistence and neutralising activity in primary school students and staff: Prospective active surveillance, June to December 2020, England.

ABSTRACT:

Background

Prospective, longitudinal SARS-CoV-2 sero-surveillance in schools across England was initiated after the first national lockdown, allowing comparison of child and adult antibody responses over time.

Methods

Prospective active serological surveillance in 46 primary schools in England tested for SARS-CoV-2 antibodies during June, July and December 2020. Samples were tested for nucleocapsid (N) and receptor binding domain (RBD) antibodies, to estimate antibody persistence at least 6 months after infection, and for the correlation of N, RBD and live virus neutralising activity.

Findings

In June 2020, 1,344 staff and 835 students were tested. Overall, 11.5% (95%CI: 9.4-13.9) and 11.3% (95%CI: 9.2-13.6; p = 0.88) of students had nucleoprotein and RBD antib

SUBMITTER: Ireland G 

PROVIDER: S-EPMC8481203 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature