Age-associated decline of monocyte insulin sensitivity in diabetic and healthy individuals.

ABSTRACT:

Objective

It is unclear whether monocyte/macrophage insulin signaling in humans is affected by type 2 diabetes (T2DM), systemic insulin sensitivity, and other unknown factors.

Research design and methods

Fifty-three adult volunteers (control group) not taking any medication and without cardiovascular risk factors, and 59 patients with T2DM (T2DM group) were included. Monocytes were isolated and cultured from all participants.

Results

In cultured monocytes, insulin-stimulated AKT and FOXO3 phosphorylation was significantly suppressed in T2DM compared with that in the control group. Insulin-stimulated phosphorylation of AKT was significantly correlated with body mass index and serum insulin level only in the control group. In both groups, significant negative correlatio

SUBMITTER: Nakamura S 

PROVIDER: S-EPMC8481716 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature