Alcohol Abstinence Rescues Hepatic Steatosis and Liver Injury <i>via</i> Improving Metabolic Reprogramming in Chronic Alcohol-Fed Mice.

ABSTRACT: Background: Alcoholic liver disease (ALD) caused by chronic ethanol overconsumption is a common type of liver disease with a severe mortality burden throughout the world. The pathogenesis of ALD is complex, and no effective clinical treatment for the disease has advanced so far. Prolonged alcohol abstinence is the most effective therapy to attenuate the clinical course of ALD and even reverse liver damage. However, the molecular mechanisms involved in alcohol abstinence-improved recovery from alcoholic fatty liver remain unclear. This study aims to systematically evaluate the beneficial effect of alcohol abstinence on pathological changes in ALD. Methods: Using the Lieber-DeCarli mouse model of ALD, we analysed whether 1-week alcohol withdrawal reversed alcohol-induced detrim

SUBMITTER: Pi A 

PROVIDER: S-EPMC8481816 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature