Serum Afamin a Novel Marker of Increased Hepatic Lipid Content.

ABSTRACT:

Aim

Afamin is a liver-produced glycoprotein, a potential early marker of metabolic syndrome. Here we investigated regulation of afamin in a course of the metabolic disease development and in response to 3-month exercise intervention.

Methods

We measured whole-body insulin sensitivity (euglycemic hyperinsulinemic clamp), glucose tolerance, abdominal adiposity, hepatic lipid content (magnetic resonance imaging/spectroscopy), habitual physical activity (accelerometers) and serum afamin (enzyme-linked immunosorbent assay) in 71 middle-aged men with obesity, prediabetes and newly diagnosed type 2 diabetes. Effects of 3-month exercise were investigated in 22 overweight-to-obese middle-aged individuals (16M/6F).

Results

Prediabetes and type 2 diabetes, but not obesity, were

SUBMITTER: Kurdiova T 

PROVIDER: S-EPMC8481912 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature