Neural effects of antidepressant medication and psychological treatments: a quantitative synthesis across three meta-analyses.

ABSTRACT:

Background

Influential theories predict that antidepressant medication and psychological therapies evoke distinct neural changes.

Aims

To test the convergence and divergence of antidepressant- and psychotherapy-evoked neural changes, and their overlap with the brain's affect network.

Method

We employed a quantitative synthesis of three meta-analyses (n = 4206). First, we assessed the common and distinct neural changes evoked by antidepressant medication and psychotherapy, by contrasting two comparable meta-analyses reporting the neural effects of these treatments. Both meta-analyses included patients with affective disorders, including major depressive disorder, generalised anxiety disorder and panic disorder. The majority were assessed using negative-valence tasks du

SUBMITTER: Nord CL 

PROVIDER: S-EPMC8481936 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature