Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza.

ABSTRACT: Current influenza vaccines do not typically confer cross-protection against antigenically mismatched strains. To develop vaccines conferring broader cross-protection, recent evidence indicates the crucial role of both cross-reactive antibodies and viral-specific CD4⁺ T cells; however, the precise mechanism of cross-protection is unclear. Furthermore, adjuvants that can efficiently induce cross-protective CD4⁺ T cells have not been identified. Here we show that CpG oligodeoxynucleotides combined with aluminum salts work as adjuvants for influenza vaccine and confer strong cross-protection in mice. Both cross-reactive antibodies and viral-specific CD4⁺ T cells contributed to cross-protection synergistically, with each individually ineffective. Furthermore, we

SUBMITTER: Shibuya M 

PROVIDER: S-EPMC8482522 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature