Sex-Specific Age-Related Changes in Methylation of Certain Genes.

ABSTRACT: The aim of the study was to conduct a functional analysis of sex-specific age-related changes in DNA methylation.

Materials and methods

The study used a GSE87571 methylation dataset obtained from the blood DNA of 729 individuals aged 14 to 94 using the Illumina Infinium HumanMethylation450K BeadChip (USA). Gene ontology analysis was performed for 3 groups of genes (females, males, and duplicates) using the PANTHER database. The DAVID platform was used to perform KEGG metabolic pathway analysis.

Results

The studies revealed unique for males and females changes in methylation of CpG sites, associated with certain metabolic processes. It was demonstrated that most of the CpG sites, for which methylation changes with age were revealed in both sexes, are associated with the

SUBMITTER: Kondakova EV 

PROVIDER: S-EPMC8482819 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature