Short and Modular Synthesis of Substituted 2-Aminopyrroles.

ABSTRACT: We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.

SUBMITTER: Diana-Rivero R 

PROVIDER: S-EPMC8483442 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature