Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome.
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ABSTRACT:
SUBMITTER: Sulaiman I
PROVIDER: S-EPMC8484067 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome.
Sulaiman Imran I Chung Matthew M Angel Luis L Tsay Jun-Chieh J JJ Wu Benjamin G BG Yeung Stephen T ST Krolikowski Kelsey K Li Yonghua Y Duerr Ralf R Schluger Rosemary R Thannickal Sara A SA Koide Akiko A Rafeq Samaan S Barnett Clea C Postelnicu Radu R Wang Chang C Banakis Stephanie S Pérez-Pérez Lizzette L Shen Guomiao G Jour George G Meyn Peter P Carpenito Joseph J Liu Xiuxiu X Ji Kun K Collazo Destiny D Labarbiera Anthony A Amoroso Nancy N Brosnahan Shari S Mukherjee Vikramjit V Kaufman David D Bakker Jan J Lubinsky Anthony A Pradhan Deepak D Sterman Daniel H DH Weiden Michael M Heguy Adriana A Evans Laura L Uyeki Timothy M TM Clemente Jose C JC de Wit Emmie E Schmidt Ann Marie AM Shopsin Bo B Desvignes Ludovic L Wang Chan C Li Huilin H Zhang Bin B Forst Christian V CV Koide Shohei S Stapleford Kenneth A KA Khanna Kamal M KM Ghedin Elodie E Segal Leopoldo N LN
Nature microbiology 20210831 10
Respiratory failure is associated with increased mortality in COVID-19 patients. There are no validated lower airway biomarkers to predict clinical outcome. We investigated whether bacterial respiratory infections were associated with poor clinical outcome of COVID-19 in a prospective, observational cohort of 589 critically ill adults, all of whom required mechanical ventilation. For a subset of 142 patients who underwent bronchoscopy, we quantified SARS-CoV-2 viral load, analysed the lower resp ...[more]
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