In Search of Effective UiO-66 Metal-Organic Frameworks for Artificial Kidney Application.

ABSTRACT: The removal of uremic toxins from patients with acute kidney injury is a key issue in improving the quality of life for people requiring peritoneal dialysis. The currently utilized method for the removal of uremic toxins from the human organism is hemodialysis, performed on semipermeable membranes where the uremic toxins, along with small molecules, are separated from proteins and blood cells. In this study, we describe a mixed-linker modulated synthesis of zirconium-based metal-organic frameworks for efficient removal of uremic toxins. We determined that the efficient adsorption of uremic toxins is achieved by optimizing the ratio between -amino functionalization of the UiO-66 structure with 75% of -NH₂ groups within organic linker structure. The maximum adsorption of hippuric

SUBMITTER: Dymek K 

PROVIDER: S-EPMC8485328 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature