Ontology highlight
ABSTRACT:
SUBMITTER: Wu K
PROVIDER: S-EPMC8486283 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Wu Kenneth K Hopkins Benjamin D BD Sanchez Roberto R DeVita Robert J RJ Pan Zhen-Qiang ZQ
Journal of cellular signaling 20210101 3
Cullin-RING E3 ubiquitin ligase 4 (CRL4) plays an essential role in cell cycle progression. Recent efforts using high throughput screening and follow up hit-to-lead studies have led to identification of small molecules <b>33-11</b> and <b>KH-4-43</b> that inhibit E3 CRL4's core ligase complex and exhibit anticancer potential. This review provides: 1) an updated perspective of E3 CRL4, including structural organization, major substrate targets and role in cancer; 2) a discussion of the challenges ...[more]