Dataset Information

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

ABSTRACT: Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.

SUBMITTER: Dudas G

PROVIDER: S-EPMC8486757 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

Dudas Gytis G Hong Samuel L SL Potter Barney I BI Calvignac-Spencer Sébastien S Niatou-Singa Frédéric S FS Tombolomako Thais B TB Fuh-Neba Terence T Vickos Ulrich U Ulrich Markus M Leendertz Fabian H FH Khan Kamran K Huber Carmen C Watts Alexander A Olendraitė Ingrida I Snijder Joost J Wijnant Kim N KN Bonvin Alexandre M J J AMJJ Martres Pascale P Behillil Sylvie S Ayouba Ahidjo A Maidadi Martin Foudi MF Djomsi Dowbiss Meta DM Godwe Celestin C Butel Christelle C Šimaitis Aistis A Gabrielaitė Miglė M Katėnaitė Monika M Norvilas Rimvydas R Raugaitė Ligita L Koyaweda Giscard Wilfried GW Kandou Jephté Kaleb JK Jonikas Rimvydas R Nasvytienė Inga I Žemeckienė Živilė Ž Gečys Dovydas D Tamušauskaitė Kamilė K Norkienė Milda M Vasiliūnaitė Emilija E Žiogienė Danguolė D Timinskas Albertas A Šukys Marius M Šarauskas Mantas M Alzbutas Gediminas G Aziza Adrienne Amuri AA Lusamaki Eddy Kinganda EK Cigolo Jean-Claude Makangara JM Mawete Francisca Muyembe FM Lofiko Emmanuel Lokilo EL Kingebeni Placide Mbala PM Tamfum Jean-Jacques Muyembe JM Belizaire Marie Roseline Darnycka MRD Essomba René Ghislain RG Assoumou Marie Claire Okomo MCO Mboringong Akenji Blaise AB Dieng Alle Baba AB Juozapaitė Dovilė D Hosch Salome S Obama Justino J Ayekaba Mitoha Ondo'o MO Naumovas Daniel D Pautienius Arnoldas A Rafaï Clotaire Donatien CD Vitkauskienė Astra A Ugenskienė Rasa R Gedvilaitė Alma A Čereškevičius Darius D Lesauskaitė Vaiva V Žemaitis Lukas L Griškevičius Laimonas L Baele Guy G

Nature communications 20211001 1

Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Δ, Y144Δ, and LLA241/243Δ. As well as documenting the suite of mutations ...[more]

PMID: 34599175

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Dataset Information

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

Publications

Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions.

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