Unknown

Dataset Information

0

The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery.


ABSTRACT: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed acute MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells, with increased frequencies of B-cell plasmablasts and double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated immune features including increased monocyte CD163 levels, emergence of a new population of immature neutrophils and, in some patients, transiently increased plasma arginase. Plasma profiling identified multiple features shared by MIS-C, Kawasaki Disease and COVID-19 and that therapeutic inhibition of IL-6 may be preferable to IL-1 or TNF-α. We identified several potential mechanisms of action for IVIG, the most commonly used drug to treat MIS-C. Finally, we showed systemic complement activation with high plasma C5b-9 levels is common in MIS-C suggesting complement inhibitors could be used to treat the disease.

SUBMITTER: Syrimi E 

PROVIDER: S-EPMC8487319 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2021-09-10 | GSE183716 | GEO
| S-EPMC10625711 | biostudies-literature
2021-09-29 | PXD025462 | Pride
| S-EPMC7480253 | biostudies-literature
| S-EPMC7649656 | biostudies-literature
| S-EPMC10052214 | biostudies-literature
| S-EPMC8187755 | biostudies-literature
2021-04-02 | GSE166489 | GEO
| S-EPMC8176784 | biostudies-literature
| S-EPMC10755832 | biostudies-literature