Targeting low-risk myelodysplastic syndrome with novel therapeutic strategies.
Ontology highlight
ABSTRACT:
SUBMITTER: Trivedi G
PROVIDER: S-EPMC8487963 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Targeting low-risk myelodysplastic syndrome with novel therapeutic strategies.
Trivedi Gaurang G Inoue Daichi D Zhang Lingbo L
Trends in molecular medicine 20210711 10
Myelodysplastic syndrome (MDS) is a group of hematopoietic disorders with limited treatment options. Anemia is a common symptom in MDS, and although erythropoiesis-stimulating agents such as erythropoietin, lenalidomide, and luspatercept are available to treat anemia, many MDS patients do not respond to these first-line therapies. Therefore, alternative drug development strategies are needed to improve therapeutic efficacy. Splicing modulators to correct splicing-related defects have shown promi ...[more]
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