A new protocol for exercise testing in COPD; improved prediction algorithm for W_MAX and validation of the endurance test in a placebo-controlled double bronchodilator study.

ABSTRACT:

Background

Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (COPD) with an individualized cardiopulmonary exercise test (ICPET) and subsequent customized endurance test (CET), which generate less interindividual spread in endurance time compared with the standard endurance test. Main objectives of this study were to improve the prediction algorithm for W_MAX for the ICPET and validate the CET by examining treatment effects on exercise performance of indacaterol/glycopyrronium (IND/GLY) compared with placebo.

Methods

COPD patients, with forced expiratory volume in 1 s (FEV₁) 40-80% predicted, were recruited. Pooled baseline data from two previous studies (n = 38) were used for

SUBMITTER: Tufvesson E 

PROVIDER: S-EPMC8488527 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature