Ontology highlight
ABSTRACT:
SUBMITTER: Escasany E
PROVIDER: S-EPMC8489029 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Escasany Elia E Lanzón Borja B García-Carrasco Almudena A Izquierdo-Lahuerta Adriana A Torres Lucía L Corrales Patricia P Rodríguez Rodríguez Ana Elena AE Luis-Lima Sergio S Martínez Álvarez Concepción C Javier Ruperez Francisco F Ros Manuel M Porrini Esteban E Rydén Mikael M Medina-Gómez Gema G
Disease models & mechanisms 20210901 9
Glomerulosclerosis and tubulointerstitial fibrosis are pathological features of chronic kidney disease. Transforming growth factor β (TGFβ) is a key player in the development of fibrosis. However, of the three known TGFβ isoforms, only TGFβ1 has an established role in fibrosis, and the pathophysiological relevance of TGFβ2 and TGFβ3 is unknown. Because Tgfb3 deficiency in mice results in early postnatal lethality, we analyzed the kidney phenotype of heterozygous Tgfb3-knockout mice (Tgfb3+/-) an ...[more]