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Natural variation of the cardiac transcriptome in humans.

ABSTRACT: We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals.

SUBMITTER: Domitrovic T

PROVIDER: S-EPMC8489943 | biostudies-literature |

REPOSITORIES: biostudies-literature

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