Natural variation of the cardiac transcriptome in humans.
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ABSTRACT:
SUBMITTER: Domitrovic T
PROVIDER: S-EPMC8489943 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Natural variation of the cardiac transcriptome in humans.
Domitrovic Tatiana T Moreira Mariana H MH Carneiro Rodolfo L RL Ribeiro-Alves Marcelo M Palhano Fernando L FL
RNA biology 20201211 10
We investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved wi ...[more]
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