The biological role of metabolic reprogramming in pancreatic cancer.
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ABSTRACT:
SUBMITTER: Suzuki T
PROVIDER: S-EPMC8491225 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
The biological role of metabolic reprogramming in pancreatic cancer.
Suzuki Tatsunori T Otsuka Motoyuki M Seimiya Takahiro T Iwata Takuma T Kishikawa Takahiro T Koike Kazuhiko K
MedComm 20201105 3
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease and highly resistant to all forms of therapy. PDAC cells reprogram their metabolism extensively to promote their survival and growth. Reflecting the vital role of altered metabolism, experimental and clinical trials targeting the rewired metabolism are currently underway. In this review, we summarize the vital role of metabolic reprogramming in the development of PDAC and the future of novel therapeutic applications. ...[more]
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