Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences.

ABSTRACT: Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and diagnosis-agnostic approach to discover brain correlates of social communication differences in ASD, ADHD, and OCD, and subgroups of individuals who share similar patterns of brain-behavior associations. A machine learning pipeline (regression clustering) was used to discover the pattern of association between structural brain measures (volume, surface area, and cortical thickness) and social communication abilities. Participants (n = 416) included children with a diagnosis of ASD (n = 192, age = 1

SUBMITTER: Kushki A 

PROVIDER: S-EPMC8491692 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature