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Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.

ABSTRACT: Greater Mekong inhabitants are exposed to pathogens, zoonotic and otherwise, that may influence SARS-CoV-2 seroreactivity. A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expected (up to 13.8 %) positivity of non-neutralizing IgG to SARS-CoV-2 spike and RBD antigens. These findings have implications for interpreting large-scale serosurveys.

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In the pre-COVID19 pandemic years of 2005 to 2011, malaria experienced Cambodians from rural settings had higher-than-expected seroreactivity to SARS-CoV-2 spike and receptor binding domain proteins.

SUBMITTER: Manning J

PROVIDER: S-EPMC8491862 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.

Manning Jessica J Zaidi Irfan I Lon Chanthap C Rosas Luz Angela LA Park Jae-Keun JK Ponce Aiyana A Bohl Jennifer J Chea Sophana S Karkanitsa Maria M Sreng Sokunthea S Rekol Huy H Chour Char Meng CM Esposito Dominic D Taubenberger Jeffery K JK Memoli Matthew J MJ Sadtler Kaitlyn K Duffy Patrick E PE Oliveira Fabiano F

medRxiv : the preprint server for health sciences 20210928

Greater Mekong inhabitants are exposed to pathogens, zoonotic and otherwise, that may influence SARS-CoV-2 seroreactivity. A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expected (up to 13.8 %) positivity of non-neutralizing IgG to SARS-CoV-2 spike and RBD antigens. These findings have implications for interpreting large-scale serosurveys.<h4>Article summary line</h4>In the pre-COVID19 pandemic years of 2005 to 2011, malaria experienc ...[more]

PMID: 34611671

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Dataset Information

Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.

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Publications

Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians.

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