Modeling spinal locomotor circuits for movements in developing zebrafish.

ABSTRACT: Many spinal circuits dedicated to locomotor control have been identified in the developing zebrafish. How these circuits operate together to generate the various swimming movements during development remains to be clarified. In this study, we iteratively built models of developing zebrafish spinal circuits coupled to simplified musculoskeletal models that reproduce coiling and swimming movements. The neurons of the models were based upon morphologically or genetically identified populations in the developing zebrafish spinal cord. We simulated intact spinal circuits as well as circuits with silenced neurons or altered synaptic transmission to better understand the role of specific spinal neurons. Analysis of firing patterns and phase relationships helped to identify possible mechanisms und

SUBMITTER: Roussel Y 

PROVIDER: S-EPMC8492062 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature