Browse
Submit Data
Databases
API
Help

Dataset Information

9 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

SARS-CoV2 neutralizing activity of ozone on porous and non-porous materials.

ABSTRACT: The COVID-19 pandemic has generated a major need for non-destructive and environmentally friendly disinfection methods. This work presents the development and testing of a disinfection process based on gaseous ozone for SARS-CoV-2-contaminated porous and non-porous surfaces. A newly developed disinfection chamber was used, equipped with a CeraPlas™ cold plasma generator that produces ozone during plasma ignition. A reduction of more than log 6 of infectious virus could be demonstrated for virus-contaminated cotton and FFP3 face masks as well as glass slides after exposure to 800 ppm ozone for 10-60 min, depending on the material. In contrast to other disinfectants, ozone can be produced quickly and cost-effectively, and its environmentally friendly breakdown product oxygen does not leave harmful residues. Disinfection with ozone could help to overcome delivery difficulties of personal protective equipment by enabling safe reuse with further applications, thereby reducing waste generation, and may allow regular disinfection of personal items with non-porous surfaces.

SUBMITTER: Wolfgruber S

PROVIDER: S-EPMC8492887 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Neutralizing Efficacy of Encapsulin Nanoparticles against SARS-CoV2 Variants of Concern.

Project description:Rapid emergence of the SARS-CoV-2 variants has dampened the protective efficacy of existing authorized vaccines. Nanoparticle platforms offer a means to improve vaccine immunogenicity by presenting multiple copies of desired antigens in a repetitive manner which closely mimics natural infection. We have applied nanoparticle display combined with the SpyTag-SpyCatcher system to design encapsulin-mRBD, a nanoparticle vaccine displaying 180 copies of the monomeric SARS-CoV-2 spike receptor-binding domain (RBD). Here we show that encapsulin-mRBD is strongly antigenic and thermotolerant for long durations. After two immunizations, squalene-in-water emulsion (SWE)-adjuvanted encapsulin-mRBD in mice induces potent and comparable neutralizing antibody titers of 105 against wild-type (B.1), alpha, beta, and delta variants of concern. Sera also neutralizes the recent Omicron with appreciable neutralization titers, and significant neutralization is observed even after a single immunization.

| S-EPMC9961482 | biostudies-literature

Sars-cov2

Project description:Samples of Rio of Janeiro Maré , Brazil

| PRJEB43953 | ENA

SARS-CoV2 envelope protein: Non-synonymous mutations and its consequences.

Project description:In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 15 (0.414%) genomes among 3617 available SARS-CoV2 genomes. More precisely, it is to be mentioned that 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contain the missense mutations over the envelope proteins of SARS-CoV2 genomes. The C-terminus motif DLLV has been changed to DFLV and YLLV in the proteins QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.

| S-EPMC7335631 | biostudies-literature

Cohesive-strength homogenisation model of porous and non-porous materials using linear comparison composites and application.

Project description:An estimation of the strength of composite materials with different strength behaviours of the matrix and inclusion is of great interest in science and engineering disciplines. Linear comparison composite (LCC) is an approach introduced for estimating the macroscopic strength of matrix-inclusion composites. The LCC approach has however not been expanded to model non-porous composites. Therefore, this paper is to fill this gap by developing a cohesive-strength method for modelling frictional composite materials, which can be porous and non-porous, using the LCC approach. The developed cohesive-strength homogenisation model represents the matrix and inclusion as a two-phase composite containing solids and pores. The model is then implemented in a multiscaling model in which porous cohesive-frictional solids intermix with each other at different scale levels classified as micro, meso and macro. The developed model satisfies an upscaling scheme and is suitable for investigating the effects of the microstructure, the composition, and the interface condition of the materials at micro scales on the macroscopic strength of the composites. To further demonstrate the application of the developed cohesive-strength homogenisation model, the cohesive-strength properties of very high strength concrete are determined using instrumented indentation, nonlinear limit analysis and second-order cone programming to obtain material properties at different scale levels.

| S-EPMC7042320 | biostudies-literature

Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides.

Project description:COVID-19 caused by SARS-CoV-2 corona virus has become a global pandemic. In the absence of drugs and vaccine, and premises of time, efforts and cost required for their development, natural resources such as herbs are anticipated to provide some help and may also offer a promising resource for drug development. Here, we have investigated the therapeutic prospective of Ashwagandha for the COVID-19 pandemic. Nine withanolides were tested in silico for their potential to target and inhibit (i) cell surface receptor protein (TMPRSS2) that is required for entry of virus to host cells and (ii) viral protein (the main protease Mpro) that is essential for virus replication. We report that the withanolides possess capacity to inhibit the activity of TMPRSS2 and Mpro. Furthermore, withanolide-treated cells showed downregulation of TMPRSS2 expression and inhibition of SARS-CoV-2 replication in vitro, suggesting that Ashwagandha may provide a useful resource for COVID-19 treatment.

| S-EPMC8188803 | biostudies-literature

SARS-COV2 study

Project description:SARS-COV2 Sequencing Study

| PRJEB58341 | ENA

SARS COV2 Study

Project description:SARS-COV-2 Sequencing Study

| PRJEB58655 | ENA

SARS-COV2-UPR

Project description:Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2

| PRJEB51271 | ENA

Fast inactivation of SARS-CoV-2 by UV-C and ozone exposure on different materials.

Project description:The extremely rapid spread of the SARS-CoV-2 has already resulted in more than 1 million reported deaths of coronavirus disease 2019 (COVID-19). The ability of infectious particles to persist on environmental surfaces is potentially considered a factor for viral spreading. Therefore, limiting viral diffusion in public environments should be achieved with correct disinfection of objects, tissues, and clothes. This study proves how two widespread disinfection systems, short-wavelength ultraviolet light (UV-C) and ozone (O3), are active in vitro on different commonly used materials. The development of devices equipped with UV-C, or ozone generators, may prevent the virus from spreading in public places.

| S-EPMC7872580 | biostudies-literature

Single particle cryo-EM dataset of Sars-CoV2 Rna dependent RNA polymerase

Project description: Not available

| EMPIAR-10741 | biostudies-other