Analysis of Immune Landscape Reveals Prognostic Significance of Cytotoxic CD4⁺ T Cells in the Central Region of pMMR CRC.

ABSTRACT:

Background

Mismatch repair proficient colorectal cancer (pMMR CRC) lacks effective treatments and has a poor prognosis, which can be attributed to the complexity of tumor microenvironment. The coordinated function of immune cells is vital to anti-tumor immunity. However, the spatial characteristics of immune cells in the pMMR CRC immune microenvironment and their relationship with clinical prognosis are not fully understood. Meanwhile, the immune modulatory effect of neoadjuvant chemotherapy (NCT), which is the first-line treatment of pMMR CRC, needs further investigation. Therefore, this study aims to explore the spatial dynamics of immune cells and its prognostic value in pMMR CRC.

Methods

We analyzed the various immune cells in formalin-fixed, paraffin-embedded tumor tiss

SUBMITTER: Qi J 

PROVIDER: S-EPMC8493090 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature