Interferon b drives intestinal regeneration after radiation.
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ABSTRACT:
SUBMITTER: Leibowitz BJ
PROVIDER: S-EPMC8494436 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Interferon b drives intestinal regeneration after radiation.
Leibowitz Brian J BJ Zhao Guangyi G Wei Liang L Ruan Hang H Epperly Michael M Chen Lujia L Lu Xinghua X Greenberger Joel S JS Zhang Lin L Yu Jian J
Science advances 20211006 41
The cGAS-STING cytosolic DNA sensing pathway is critical for host defense. Here, we report that cGAS-STING–dependent type 1 interferon (IFN) response drives intestinal regeneration and animal recovery from radiation injury. <i>STING</i> deficiency has no effect on radiation-induced DNA damage or crypt apoptosis but abrogates epithelial IFN-β production, local inflammation, innate transcriptional response, and subsequent crypt regeneration. <i>cGAS</i> KO, <i>IFNAR1</i> KO, or <i>CCR2</i> KO also ...[more]
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