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Cellular anatomy of the mouse primary motor cortex.


ABSTRACT: An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted1. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture.

SUBMITTER: Munoz-Castaneda R 

PROVIDER: S-EPMC8494646 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Cellular anatomy of the mouse primary motor cortex.

Muñoz-Castañeda Rodrigo R   Zingg Brian B   Matho Katherine S KS   Chen Xiaoyin X   Wang Quanxin Q   Foster Nicholas N NN   Li Anan A   Narasimhan Arun A   Hirokawa Karla E KE   Huo Bingxing B   Bannerjee Samik S   Korobkova Laura L   Park Chris Sin CS   Park Young-Gyun YG   Bienkowski Michael S MS   Chon Uree U   Wheeler Diek W DW   Li Xiangning X   Wang Yun Y   Naeemi Maitham M   Xie Peng P   Liu Lijuan L   Kelly Kathleen K   An Xu X   Attili Sarojini M SM   Bowman Ian I   Bludova Anastasiia A   Cetin Ali A   Ding Liya L   Drewes Rhonda R   D'Orazi Florence F   Elowsky Corey C   Fischer Stephan S   Galbavy William W   Gao Lei L   Gillis Jesse J   Groblewski Peter A PA   Gou Lin L   Hahn Joel D JD   Hatfield Joshua T JT   Hintiryan Houri H   Huang Junxiang Jason JJ   Kondo Hideki H   Kuang Xiuli X   Lesnar Philip P   Li Xu X   Li Yaoyao Y   Lin Mengkuan M   Lo Darrick D   Mizrachi Judith J   Mok Stephanie S   Nicovich Philip R PR   Palaniswamy Ramesh R   Palmer Jason J   Qi Xiaoli X   Shen Elise E   Sun Yu-Chi YC   Tao Huizhong W HW   Wakemen Wayne W   Wang Yimin Y   Yao Shenqin S   Yuan Jing J   Zhan Huiqing H   Zhu Muye M   Ng Lydia L   Zhang Li I LI   Lim Byung Kook BK   Hawrylycz Michael M   Gong Hui H   Gee James C JC   Kim Yongsoo Y   Chung Kwanghun K   Yang X William XW   Peng Hanchuan H   Luo Qingming Q   Mitra Partha P PP   Zador Anthony M AM   Zeng Hongkui H   Ascoli Giorgio A GA   Josh Huang Z Z   Osten Pavel P   Harris Julie A JA   Dong Hong-Wei HW  

Nature 20211006 7879


An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted<sup>1</sup>. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and vi  ...[more]

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