Maternal exposure to life events during pregnancy and congenital heart disease in offspring: a case-control study in a Chinese population.

ABSTRACT:

Background

Previous studies have suggested that maternal stress could increase the risk of some adverse pregnancy outcomes, but evidence on congenital heart disease (CHD) is limited. We aimed to explore the association between maternal exposure to life events during pregnancy and CHD in offspring.

Methods

The data was based on an unmatched case-control study about CHD conducted in Shaanxi province of China from 2014 to 2016. We included 2280 subjects, 699 in the case group and 1581 in the control group. The cases were infants or fetuses diagnosed with CHD, and the controls were infants without any birth defects. The life events were assessed by the Life Events Scale for Pregnant Women, and were divided into positive and negative events for synchronous analysis. A directed ac

SUBMITTER: Li J 

PROVIDER: S-EPMC8496089 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature