The correlation of WDR76 expression with survival outcomes and immune infiltrates in lung adenocarcinoma.

ABSTRACT:

Background

WD repeat domain 76 (WDR76) is a predicted member of the WD40-repeat-containing domain superfamily and possibly involves in various biological processes, but its function in cancers is poorly characterized. This study aimed to evaluate the role of WDR76 in the prognosis and immune infiltrates of lung adenocarcinoma (LUAD).

Methods

WDR76 expressions in LUAD tissues and normal tissues were primarily compared by The Cancer Genome Atlas (TCGA) database, and were validated in cohorts from Gene Expression Omnibus (GEO) database. The associations between WDR76 expression and clinicopathologic characteristics were analyzed. Kaplan-Meier and Cox regression analyses were performed to determine the impact of WDR76 expression on survival outcomes. The protein interaction netw

SUBMITTER: Fang L 

PROVIDER: S-EPMC8496460 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature