TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
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ABSTRACT:
SUBMITTER: Park HS
PROVIDER: S-EPMC8496541 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Park Hee-Seon HS Song Ji-Won JW Park Jin-Ho JH Lim Byung-Kwan BK Moon Og-Sung OS Son Hwa-Young HY Lee Jae-Hyuk JH Gao Bin B Won Young-Suk YS Kwon Hyo-Jung HJ
Autophagy 20201116 9
Impaired macroautophagy/autophagy has been implicated in experimental and human nonalcoholic steatohepatitis (NASH). However, the mechanism underlying autophagy dysregulation in NASH is largely unknown. Here, we investigated the role and mechanism of TXNIP/VDUP1 (thioredoxin interacting protein), a key mediator of cellular stress responses, in the pathogenesis of NASH. Hepatic TXNIP expression was upregulated in nonalcoholic fatty liver disease (NAFLD) patients and in methionine choline-deficien ...[more]
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