Maternal vs Fetal Origin of Placental Intervillous Thrombi.

ABSTRACT:

Objectives

To determine maternal vs fetal origin for blood in placental intervillous thrombi (IVTs).

Methods

We used comparative analysis of microsatellites (short tandem repeats [STRs]), sex chromosome fluorescence in situ hybridization (FISH), and immunohistochemistry (IHC) for fetal (ɑ-fetoprotein [AFP]) and maternal (immunoglobulin M [IgM]) serum proteins to distinguish the origin of IVTs. Using an informatics approach, we tested the association between IVTs and fetomaternal hemorrhage (FMH).

Results

In 9 of 10 cases, the preponderance of evidence showed that the thrombus was mostly or entirely maternal in origin. In 1 case, the thrombus was of mixed origins. STR testing was prone to contamination by entrapped fetal villi. FISH was useful but limited only to cases

SUBMITTER: Sukhanova M 

PROVIDER: S-EPMC8500002 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature