Biventricular Myocardial Fibrosis and Sudden Death in Patients With Brugada Syndrome.

ABSTRACT:

Background

Electrophysiological, imaging, and pathological studies have reported the presence of subtle structural abnormalities in hearts from patients with Brugada syndrome (BrS). However, data concerning disease involvement outside of the right ventricular outflow tract are limited.

Objectives

This study sought to characterize the presence and distribution of ventricular myocardial fibrosis in a cohort of decedents experiencing sudden cardiac death caused by BrS.

Methods

The authors evaluated 28 whole hearts from consecutive sudden cardiac death cases attributed to BrS and 29 hearts from a comparator group comprised of noncardiac deaths (control subjects). Cardiac tissue from 6 regions across the right and left ventricle were stained with Picrosirius red for collag

SUBMITTER: Miles C 

PROVIDER: S-EPMC8504200 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature