Ontology highlight
ABSTRACT: Background/aims
Argon plasma coagulation (APC) is the most commonly used endoscopic treatment for gastric antral vascular ectasia (GAVE). Endoscopic band ligation (EBL) has emerged as an alternative therapy. Our goal was to evaluate the feasibility, efficacy, and safety of APC and EBL for the treatment of GAVE. This is the first systematic review that included only randomized controlled trials (RCTs) on this topic.Methods
A comprehensive search was performed using electronic databases to identify RCTs comparing APC and EBL for the treatment of GAVE following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.Results
Four RCTs were included, with a total of 204 patients. EBL was related to higher endoscopic eradication rates risk difference [RD], 0.29; 95% confidence interval [CI] [0.14, 0.44]; I2=0%) and less bleeding recurrence than APC (RD, 0.29; 95% CI [0.15, 0.44]; I2=0%). Patients treated with EBL required fewer blood transfusions (mean difference [MD], 1.49; 95% CI [0.28, 2.71]; I2=96%) and hospitalizations (MD, 0.29; 95% CI [0.19, 0.39]; I2=0%). The number of sessions required for the obliteration of lesions was higher with APC. There was no difference in the incidence of adverse events.Conclusion
EBL is superior to APC in the treatment of GAVE in terms of endoscopic eradication rates, recurrence of bleeding, and transfusion requirements.
SUBMITTER: Hirsch BS
PROVIDER: S-EPMC8505186 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Hirsch Bruno Salomão BS Ribeiro Igor Braga IB Funari Mateus Pereira MP de Moura Diogo Turiani Hourneaux DTH Matuguma Sergio Eiji SE Sánchez-Luna Sergio A SA Mancini Fabio Catache FC de Oliveira Guilherme Henrique Peixoto GHP Bernardo Wanderley Marques WM de Moura Eduardo Guimarães Hourneaux EGH
Clinical endoscopy 20210531 5
<h4>Background/aims</h4>Argon plasma coagulation (APC) is the most commonly used endoscopic treatment for gastric antral vascular ectasia (GAVE). Endoscopic band ligation (EBL) has emerged as an alternative therapy. Our goal was to evaluate the feasibility, efficacy, and safety of APC and EBL for the treatment of GAVE. This is the first systematic review that included only randomized controlled trials (RCTs) on this topic.<h4>Methods</h4>A comprehensive search was performed using electronic data ...[more]