Does Self-Reassurance Reduce Neural and Self-Report Reactivity to Negative Life Events?
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ABSTRACT:
SUBMITTER: Kim JJ
PROVIDER: S-EPMC8505763 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Research has shown that engaging in self-reassurance, a compassionately motivated cognitive relating style, can down-regulate neural markers of threat and pain. Whilst important, the relationship between neural and self-report markers of reassurance are largely unknown. Here we analyzed previously published fMRI data which measured neural responses when participants engaged in self-reassurance toward a mistake, setback, or failure. Within the present paper, we identified correlations between regions of interest extracted during self-reassurance with fMRI and self-report data. Using generalized additive modelling, we show that participants with greater inadequate forms of self-criticism exhibited greater neural activation within the medial prefrontal cortex (MPFC) and anterior insula (AI). Furthermore, a relationship between greater fears of expressing compassion to the self and neural activation within the MPFC returned non-significant after correction for multiple comparisons. No significant relationships were observed between brain activation and hated and reassuring forms of self-criticism. Our results identify preliminary evidence for neural activity during self-reassurance as correlated with self-report markers, and we outline a method for modelling neural and self-report data which can be applied to future studies in compassion science, particularly with a clinical sample.
| S-EPMC7538506 | biostudies-literature
Project description:Several recent studies suggest that placebos administered without deception (i.e., non-deceptive placebos) can help people manage a variety of highly distressing clinical disorders and nonclinical impairments. However, whether non-deceptive placebos represent genuine psychobiological effects is unknown. Here we address this issue by demonstrating across two experiments that during a highly arousing negative picture viewing task, non-deceptive placebos reduce both a self-report and neural measure of emotional distress, the late positive potential. These results show that non-deceptive placebo effects are not merely a product of response bias. Additionally, they provide insight into the neural time course of non-deceptive placebo effects on emotional distress and the psychological mechanisms that explain how they function.
| S-EPMC7391658 | biostudies-literature
Project description:Negative life events (NLE) contribute to anxiety and depression disorders, but their relationship with brain functioning in adolescence has rarely been studied. We hypothesized that neural response to social threat would relate to NLE in the frontal-limbic emotional regions. Participants (N = 685) were drawn from the Imagen database of 14-year-old community adolescents recruited in schools. They underwent functional MRI while viewing angry and neutral faces, as a probe to neural response to social threat. Lifetime NLEs were assessed using the 'distress', 'family' and 'accident' subscales from a life event dimensional questionnaire. Relationships between NLE subscale scores and neural response were investigated. Links of NLE subscales scores with anxiety or depression outcomes at the age of 16 years were also investigated. Lifetime 'distress' positively correlated with ventral-lateral orbitofrontal and temporal cortex activations during angry face processing. 'Distress' scores correlated with the probabilities of meeting criteria for Generalized Anxiety Disorder or Major Depressive Disorder at the age of 16 years. Lifetime 'family' and 'accident' scores did not relate with neural response or follow-up conditions, however. Thus, different types of NLEs differentially predicted neural responses to threat during adolescence, and differentially predicted a de novo internalizing condition 2 years later. The deleterious effect of self-referential NLEs is suggested.
| S-EPMC5141952 | biostudies-literature
Project description:BackgroundIn the current study we investigated impulsivity and negative life events in relation to non-suicidal self-injury (NSSI) in correctional settings.MethodsA total of 141 male justice-involved juveniles participated in our cross-sectional study, aged between 14 and 21 years old (M = 17.75; SD = 1.38). Data collection took place in correctional institutions in Hungary. A binary logistic regression was conducted to investigate possible associations between NSSI, impulsivity and negative life events.ResultsLifetime prevalence of NSSI was 53.9% (N = 76). In a binary logistic regression model, only negative romantic relationship events were significantly associated with the risk of current NSSI (OR = 1.29; 95% CI = [1.06-1.56]). Other types of negative life events (family-related, friendship-related), impulsivity, age and conviction status did not have a significant role in the model.ConclusionsThe results suggest that juvenile offenders should receive additional support to manage stress that is associated with negative life events, especially problems in romantic relationships. It is essential to help young inmates to find an adaptive way of reducing stress caused by negative relationship life events.
| S-EPMC8361803 | biostudies-literature
Project description:A population sample of 10,049 women living in Guanacaste, Costa Rica, was recruited into a natural history of human papillomavirus (HPV) and cervical neoplasia study in 1993-1994. At the enrollment visit, we applied multiple state-of-the-art cervical cancer screening methods to detect prevalent cervical cancer and to prevent subsequent cervical cancers by the timely detection and treatment of precancerous lesions. Women were screened at enrollment with 3 kinds of cytology (often reviewed by more than one pathologist), visual inspection and cervicography. Any positive screening test led to colposcopic referral and biopsy and/or excisional treatment of CIN2 or worse. We retrospectively tested stored specimens with an early HPV test (hybrid capture tube test) and for >40 HPV genotypes using a research PCR assay. We followed women typically 5-7 years and some up to 11 years. Nonetheless, 16 cases of invasive cervical cancer were diagnosed during follow-up. Six cancer cases were failures at enrollment to detect abnormalities by cytology screening; 3 of the 6 were also negative at enrollment by sensitive HPV DNA testing. Seven cancers represent failures of colposcopy to diagnose cancer or a precancerous lesion in screen-positive women. Finally, 3 cases arose despite attempted excisional treatment of precancerous lesions. Based on this evidence, we suggest that no current secondary cervical cancer prevention technologies applied once in a previously under-screened population is likely to be 100% efficacious in preventing incident diagnoses of invasive cervical cancer.
| S-EPMC2766540 | biostudies-literature
Project description:ObjectiveThis study aimed to examine the association between negative life events (NLEs) and attempted suicide in rural China.MethodsSix rural counties were selected from disease surveillance points in Shandong province, China. A total of 409 suicide attempters in rural areas between October 1, 2009, and March 31, 2011, and an equal number of matched controls were interviewed. We compared negative life events experienced within 1 month, 1-3 months, 3-6 months, and 6-2 months prior to attempted suicide for cases and prior to interview for controls. We used multivariate logistic regression to examine the association between NLEs and attempted suicide.ResultsSuicide attempters experienced more NLEs within the last year prior to suicide attempt than controls prior to interview (83.1% vs. 33.5%). There was a significant dose-response relationship between NLEs experienced within the last year and increased risk of attempted suicide. Timing of NLEs analysis showed that NLEs experienced in the last month and 6-12 months prior to suicide attempt were significantly associated with elevated risk of attempted suicide, even after adjusting for mental disorders and demographic factors. Of NLEs, quarrelling with spouse, quarrelling with other family members, conflicting with friends or neighbors, family financial difficulty, and serious illness were independently related to attempted suicide.ConclusionNLEs are significantly associated with increased risk for attempted suicide in rural China. Stress management and intervention may be important to prevent suicidal behavior in rural China.
| S-EPMC4303417 | biostudies-literature
Project description:BACKGROUND:Alcohol abuse is a common and costly practice. Individuals high in negative urgency, the tendency to act rashly when experiencing negative emotions, are at particular risk for abusing alcohol. Alcohol abuse among individuals high in negative urgency may be due to (a) increased activity in the brain's striatum, (b) decreased activity in brain regions associated with self-control, or (c) a combination of the two. METHODS:Thirty eight non-alcohol-dependent participants completed a measure of negative urgency and then underwent functional magnetic resonance imaging (fMRI) while passively viewing pleasant and alcohol images. RESULTS:Alcohol images (as compared to pleasant images) were associated with activation in the caudate nucleus, a brain region associated with linking reward to external stimuli. Negative urgency (above and beyond other facets of impulsivity) correlated positively with this caudate activation in response to alcohol images. Alcohol images and negative urgency were unassociated with activity in the lateral prefrontal cortex, a self-regulatory brain region. CONCLUSIONS:These findings provide initial support that the alcohol abuse observed among individuals high in negative urgency may be due, in part, to heightened reactivity in the striatum to alcohol. Investigating such neural contributors to self-regulation failure is crucial to reducing substance abuse.
| S-EPMC7408295 | biostudies-literature
Project description:ObjectiveExperimental evidence suggests that inadequate sleep disrupts next-day affective processing and evokes greater stress reactivity. However, less research has focused on whether sleep predicts next-day affective reactivity to naturally occurring stressors and positive events in daily life, as well as the reversed direction of association (i.e., affective reactivity to daily events as predictors of subsequent sleep). The purpose of this study was to evaluate the within-person, bidirectional associations between nightly sleep duration and day-to-day fluctuations in affect related to stressors and positive events.MethodAdults ages 33-84 (N = 1,982, 57% female) in the U.S. National Study of Daily Experiences II reported sociodemographics and chronic conditions at baseline, then completed telephone interviews for 8 consecutive days about their sleep duration, daily stressors, positive events, and affect.ResultsPrior-night sleep duration moderated the link between current-day events and positive affect, but not negative affect. Specifically, nights of shorter-than-usual sleep duration predicted more pronounced decreases in positive affect in response to daily stressors, as well as smaller increases in positive affect in response to daily positive events. Results for the reversed direction of association showed no evidence for affective reactivity to daily events as predictors of subsequent sleep duration. People with more chronic conditions were more reactive to positive events, particularly after nights of longer sleep.ConclusionAffective reactivity to daily stressors and positive events vary based upon sleep duration, such that sleep loss may amplify loss of positive affect on days with stressors, as well as reduce positive affective responsiveness to positive events. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
| S-EPMC7704897 | biostudies-literature
Project description:Self-control often fails when people experience negative emotions. Negative urgency represents the dispositional tendency to experience such self-control failure in response to negative affect. Neither the neural underpinnings of negative urgency nor the more general phenomenon of self-control failure in response to negative emotions are fully understood. Previous theorizing suggests that an insufficient, inhibitory response from the prefrontal cortex may be the culprit behind such self-control failure. However, we entertained an alternative hypothesis: negative emotions lead to self-control failure because they excessively tax inhibitory regions of the prefrontal cortex. Using fMRI, we compared the neural activity of people high in negative urgency with controls on an emotional, inhibitory Go/No-Go task. While experiencing negative (but not positive or neutral) emotions, participants high in negative urgency showed greater recruitment of inhibitory brain regions than controls. Suggesting a compensatory function, inhibitory accuracy among participants high in negative urgency was associated with greater prefrontal recruitment. Greater activity in the anterior insula on negatively-valenced, inhibitory trials predicted greater substance abuse one month and one year after the MRI scan among individuals high in negative urgency. These results suggest that, among people whose negative emotions often lead to self-control failure, excessive reactivity of the brain's regulatory resources may be the culprit.
| S-EPMC4851933 | biostudies-literature
Project description:IntroductionNumerous studies report smokers' increased craving and physiological arousal when exposed to cigarette stimuli. These responses are attributed to learning processes (e.g., classical conditioning) and are associated with motivational factors that maintain nicotine dependence. However, much less is known about the degree to which these responses are maintained or diminished during quitting.MethodsTreatment-seeking smokers (N = 104) were randomly assigned to continue smoking or to enter a 2-week treatment program. Abstainers (n = 25) were continuously abstinent for 14-17 days at the time of testing. Control subjects (n = 38) continued to smoke at their usual rate. Participants who were assigned to treatment but resumed smoking during the study (n = 41) were considered to be relapsers. Approximately 2 weeks after baseline measurements, abstainers and controls viewed a series of neutral (n = 12) and cigarette (n = 12) pictures, rating them for craving and arousal (feelings of calm vs. excitement).ResultsNon-cued craving (measured during exposure to neutral cues) was diminished in abstaining smokers. However, cigarette cues produced craving increases of the same magnitude in both abstainers and controls, showing that these cues still had evocative power for both groups. Abstaining smokers, who were not physiologically monitored, had lower self-reports of arousal to cigarette pictures than did controls, but the groups did not differ in arousal to neutral pictures.DiscussionThese findings suggest that the foundations of cue-induced craving, generalized craving, and physiological arousal associated with craving may arise from separate processes.
| S-EPMC2699928 | biostudies-literature