Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer.

ABSTRACT: The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are the largest class of protein-protein interaction modules, involved in several cellular pathways such as signal transduction, cell-cell junctions, cell polarity and adhesion, and protein trafficking. Because of that, dysregulation of PDZ domain function often causes the onset of pathologies, thus making this family of domains an interesting pharmaceutical target. In this review article we provide an overview of the structural and functional features of PDZ domains and their involvement in the cellular and molecular pathways at the basis of different human pathologies. We also discuss some of the strategies that have been developed wi

SUBMITTER: Nardella C 

PROVIDER: S-EPMC8506081 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature