Ontology highlight
ABSTRACT:
SUBMITTER: Messerschmidt VL
PROVIDER: S-EPMC8507495 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Messerschmidt Victoria L VL Chintapula Uday U Kuriakose Aneetta E AE Laboy Samantha S Truong Thuy Thi Dang TTD Kydd LeNaiya A LA Jaworski Justyn J Pan Zui Z Sadek Hashem H Nguyen Kytai T KT Lee Juhyun J
Frontiers in cardiovascular medicine 20210928
Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. When the signal is lost, maldevelopment occurs and leads to a lethal state. Delivering exogenous genetic materials encoding Notch into cells can reestablish downstream signaling and rescue cellular functions. In this study, we utilized the negatively charged and FDA approved polymer poly(lactic-co-glycolic acid) to encapsulate Notch Intracellular Domain-containing plasmid ...[more]