Ontology highlight
ABSTRACT:
SUBMITTER: Gu Z
PROVIDER: S-EPMC85079 | biostudies-literature | 2000 Jan
REPOSITORIES: biostudies-literature
Gu Z Z Flemington C C Chittenden T T Zambetti G P GP
Molecular and cellular biology 20000101 1
DNA damage and/or hyperproliferative signals activate the wild-type p53 tumor suppressor protein, which induces a G(1) cell cycle arrest or apoptosis. Although the mechanism of p53-mediated cell cycle arrest is fairly well defined, the p53-dependent pathway regulating apoptosis is poorly understood. Here we report the functional characterization of murine ei24 (also known as PIG8), a gene directly regulated by p53, whose overexpression negatively controls cell growth and induces apoptotic cell d ...[more]