Ontology highlight
ABSTRACT:
SUBMITTER: Kittel-Boselli E
PROVIDER: S-EPMC8508561 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Kittel-Boselli Enrico E Soto Karla Elizabeth González KEG Loureiro Liliana Rodrigues LR Hoffmann Anja A Bergmann Ralf R Arndt Claudia C Koristka Stefanie S Mitwasi Nicola N Kegler Alexandra A Bartsch Tabea T Berndt Nicole N Altmann Heidi H Fasslrinner Frederick F Bornhäuser Martin M Bachmann Michael Philipp MP Feldmann Anja A
Cancers 20210924 19
Clinical translation of novel immunotherapeutic strategies such as chimeric antigen receptor (CAR) T-cells in acute myeloid leukemia (AML) is still at an early stage. Major challenges include immune escape and disease relapse demanding for further improvements in CAR design. To overcome such hurdles, we have invented the switchable, flexible and programmable adaptor Reverse (Rev) CAR platform. This consists of T-cells engineered with RevCARs that are primarily inactive as they express an extrace ...[more]