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Synthesis and Characterization of a Novel Biocompatible Alloy, Ti-Nb-Zr-Ta-Sn.

ABSTRACT: Many current-generation biomedical implants are fabricated from the Ti-6Al-4V alloy because it has many attractive properties, such as low density and biocompatibility. However, the elastic modulus of this alloy is much larger than that of the surrounding bone, leading to bone resorption and, eventually, implant failure. In the present study, we synthesized and performed a detailed analysis of a novel low elastic modulus Ti-based alloy (Ti-28Nb-5Zr-2Ta-2Sn (TNZTS alloy)) using a variety of methods, including scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and tensile test. Additionally, the in vitro biocompatibility of the TNZTS alloy was evaluated using SCP-1, SaOs-2, and THP-1 cell lines and primary human osteoblasts. Compared to Ti-6Al-4V, the elastic modulus of TNZTS alloy was significantly lower, while measures of its in vitro biocompatibility are comparable. O₂ plasma treatment of the surface of the alloy significantly increased its hydrophilicity and, hence, its in vitro biocompatibility. TNZTS alloy specimens did not induce the release of cytokines by macrophages, indicating that such scaffolds would not trigger inflammatory responses. The present results suggest that the TNZTS alloy may have potential as an alternative to Ti-6Al-4V.

SUBMITTER: Khrunyk YY

PROVIDER: S-EPMC8509052 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Nano-Topographical Control of Ti-Nb-Zr Alloy Surfaces for Enhanced Osteoblastic Response.

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| S-EPMC5126583 | biostudies-literature

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| S-EPMC8715753 | biostudies-literature

Novel Ti-Zr-Hf-Fe Nanostructured Alloy for Biomedical Applications.

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| S-EPMC5452764 | biostudies-other

Effect of Zr Content on Phase Stability, Deformation Behavior, and Young's Modulus in Ti-Nb-Zr Alloys.

Project description:Ti alloys have attracted continuing research attention as promising biomaterials due to their superior corrosion resistance and biocompatibility and excellent mechanical properties. Metastable ?-type Ti alloys also provide several unique properties such as low Young's modulus, shape memory effect, and superelasticity. Such unique properties are predominantly attributed to the phase stability and reversible martensitic transformation. In this study, the effects of the Nb and Zr contents on phase constitution, transformation temperature, deformation behavior, and Young's modulus were investigated. Ti-Nb and Ti-Nb-Zr alloys over a wide composition range, i.e., Ti-(18-40)Nb, Ti-(15-40)Nb-4Zr, Ti-(16-40)Nb-8Zr, Ti-(15-40)Nb-12Zr, Ti-(12-17)Nb-18Zr, were fabricated and their properties were characterized. The phase boundary between the ? phase and the ?'' martensite phase was clarified. The lower limit content of Nb to suppress the martensitic transformation and to obtain a single ? phase at room temperature decreased with increasing Zr content. The Ti-25Nb, Ti-22Nb-4Zr, Ti-19Nb-8Zr, Ti-17Nb-12Zr and Ti-14Nb-18Zr alloys exhibit the lowest Young's modulus among Ti-Nb-Zr alloys with Zr content of 0, 4, 8, 12, and 18 at.%, respectively. Particularly, the Ti-14Nb-18Zr alloy exhibits a very low Young's modulus less than 40 GPa. Correlation among alloy composition, phase stability, and Young's modulus was discussed.

| S-EPMC7014103 | biostudies-literature

Realistic microstructure evolution of complex Ta-Nb-Hf-Zr high-entropy alloys by simulation techniques.

Project description:Over last 15 years high-entropy alloys (HEAs) and complex concentrated alloys (CCAs) have gained much appreciation for their numerous superior properties. In this paper we have shown a novel simulation methodology to realistically predict the nanometer level local structural features of complex Ta0.25Nb0.25Hf0.25Zr0.25 HEA. This involves prediction of the morphology of the short-range clustering (SRCs), their quantitative atomic composition at the nano level and the thermodynamic aspects. An alloy structure model containing 11664 atoms was created and this was subjected to structure evolution at 1800?°C. The structure evolution technique is based on a combined hybrid Monte Carlo and molecular dynamics (MC/MD) approach. The simulated results from this work are further validated against experiments and material characterizations reported in literature and done by high-resolution transmission electron micrograph (HRTEM) for the nano-level microstructure, atom probe tomography (APT) for the local chemical compositions and X-ray diffraction at synchrotron sources for the local lattice relaxation effects. This work qualitatively and quantitatively reproduces the materials characterization results reasonably well from the developed simulation methodologies. The structure evolution methods as described in this work are based on independent computer simulations and does not involve any manual intervention for input based on experiments on evolving SRCs. This work shows the potential of utilizing MC/MD based computational methods to reduce the number of costly experimental characterizations and accelerate the pace for materials development.

| S-EPMC6841691 | biostudies-literature

Plastic deformation behaviour of single-crystalline martensite of Ti-Nb shape memory alloy.

Project description:?-Ti alloys have attracted considerable attention as new biomedical shape memory alloys. Given the critical importance of the plastic deformation in the martensite phase for the shape memory effect and superelasticity, we investigated here the plastic deformation behaviour of a single crystal of ?? (orthorhombic) martensite of Ti-27?mol%Nb shape memory alloy obtained by the stress-induced martensitic transformation of a single crystal of the parent ? phase. Four operative plastic deformation modes were observed, including two dislocation slips and two twinnings. To the best of our knowledge, two of these plastic deformation modes (one dislocation slip and one twinning) were discovered for the first time in this study. The identified slip and twinning systems in the martensite phase have corresponding slip and twinning systems in the parent ? phase with which they share many similarities. Therefore, we believe that the plastic deformation of the ?? martensite is inherited from that of the parent ? phase.

| S-EPMC5691214 | biostudies-literature

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