Ontology highlight
ABSTRACT:
SUBMITTER: Kurokawa N
PROVIDER: S-EPMC8509488 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Kurokawa Nina N Midorikawa Rio R Nakamura Manami M Noguchi Keiichi K Morishima Ken K Inoue Rintaro R Sugiyama Masaaki M Yohda Masafumi M
International journal of molecular sciences 20211006 19
HspB1 is a mammalian sHsp that is ubiquitously expressed in almost all tissues and involved in regulating many vital functions. Although the recent crystal structure of human HspB1 showed that 24 monomers form the oligomeric complex of human HspB1 in a spherical configuration, the molecular architecture of HspB1 is still controversial. In this study, we examined the oligomeric structural change of CgHspB1 by sedimentation velocity analytical ultracentrifugation. At the low temperature of 4 °C, C ...[more]