Dataset Information

Bayesian Semiparametric Longitudinal Drift-Diffusion Mixed Models for Tone Learning in Adults.

ABSTRACT: Understanding how adult humans learn nonnative speech categories such as tone information has shed novel insights into the mechanisms underlying experience-dependent brain plasticity. Scientists have traditionally examined these questions using longitudinal learning experiments under a multi-category decision making paradigm. Drift-diffusion processes are popular in such contexts for their ability to mimic underlying neural mechanisms. Motivated by these problems, we develop a novel Bayesian semiparametric inverse Gaussian drift-diffusion mixed model for multi-alternative decision making in longitudinal settings. We design a Markov chain Monte Carlo algorithm for posterior computation. We evaluate the method's empirical performances through synthetic experiments. Applied to our motivating longitudinal tone learning study, the method provides novel insights into how the biologically interpretable model parameters evolve with learning, differ between input-response tone combinations, and differ between well and poorly performing adults. supplementary materials for this article, including a standardized description of the materials available for reproducing the work, are available as an online supplement.

SUBMITTER: Paulon G

PROVIDER: S-EPMC8513775 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Bayesian Semiparametric Longitudinal Drift-Diffusion Mixed Models for Tone Learning in Adults.

Paulon Giorgio G Llanos Fernando F Chandrasekaran Bharath B Sarkar Abhra A

Journal of the American Statistical Association 20200908 535

Understanding how adult humans learn nonnative speech categories such as tone information has shed novel insights into the mechanisms underlying experience-dependent brain plasticity. Scientists have traditionally examined these questions using longitudinal learning experiments under a multi-category decision making paradigm. Drift-diffusion processes are popular in such contexts for their ability to mimic underlying neural mechanisms. Motivated by these problems, we develop a novel Bayesian sem ...[more]

PMID: 34650315

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Project description:BackgroundIn clinical trials and epidemiological research, mixed-effects models are commonly used to examine population-level and subject-specific trajectories of biomarkers over time. Despite their increasing popularity and application, the specification of these models necessitates a great deal of care when analysing longitudinal data with non-linear patterns and asymmetry. Parametric (linear) mixed-effect models may not capture these complexities flexibly and adequately. Additionally, assuming a Gaussian distribution for random effects and/or model errors may be overly restrictive, as it lacks robustness against deviations from symmetry.MethodsThis paper presents a semiparametric mixed-effects model with flexible distributions for complex longitudinal data in the Bayesian paradigm. The non-linear time effect on the longitudinal response was modelled using a spline approach. The multivariate skew-t distribution, which is a more flexible distribution, is utilized to relax the normality assumptions associated with both random-effects and model errors.ResultsTo assess the effectiveness of the proposed methods in various model settings, simulation studies were conducted. We then applied these models on chronic kidney disease (CKD) data and assessed the relationship between covariates and estimated glomerular filtration rate (eGFR). First, we compared the proposed semiparametric partially linear mixed-effect (SPPLM) model with the fully parametric one (FPLM), and the results indicated that the SPPLM model outperformed the FPLM model. We then further compared four different SPPLM models, each assuming different distributions for the random effects and model errors. The model with a skew-t distribution exhibited a superior fit to the CKD data compared to the Gaussian model. The findings from the application revealed that hypertension, diabetes, and follow-up time had a substantial association with kidney function, specifically leading to a decrease in GFR estimates.ConclusionsThe application and simulation studies have demonstrated that our work has made a significant contribution towards a more robust and adaptable methodology for modeling intricate longitudinal data. We achieved this by proposing a semiparametric Bayesian modeling approach with a spline smoothing function and a skew-t distribution.

Dataset Information

Bayesian Semiparametric Longitudinal Drift-Diffusion Mixed Models for Tone Learning in Adults.

Publications

Bayesian Semiparametric Longitudinal Drift-Diffusion Mixed Models for Tone Learning in Adults.

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