Acacia senegal gum attenuates systemic toxicity in CCl₄-intoxicated rats via regulation of the ROS/NF-κB signaling pathway.

ABSTRACT: Acacia senegal (AS) gum (Gum Arabic) is a natural emulsifier exudate from the branches and trunk of Acacia trees and it is recognized by the Food and Drug Administration (FDA) agency as a secure dietary fiber. The present research evaluated the systemic oxidative and necroinflammatory stress induced by CCl₄ administration and the alleviating effect of AS gum aqueous extract (ASE, 7.5 g/Kg b.w.). The results demonstrated the presence of certain phenolic compounds in ASE, as well as its in vitro potent scavenging ability against ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), NO, and lipid peroxide radicals. Also, the outcomes revealed an improvement in the CCl₄-induced liver, lung, brain, and spleen toxicity by reducing the levels of ROS, lipid peroxidati

SUBMITTER: Abu-Serie MM 

PROVIDER: S-EPMC8514504 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature