Ontology highlight
ABSTRACT:
SUBMITTER: Huang AS
PROVIDER: S-EPMC8515646 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20211012 12
Latent intact HIV-1 proviruses persist in a small subset of long-lived CD4+ T cells that can undergo clonal expansion in vivo. Expanded clones of CD4+ T cells dominate latent reservoirs in individuals on long-term antiretroviral therapy (ART) and represent a major barrier to HIV-1 cure. To determine how integration landscape might contribute to latency, we analyzed integration sites of near full length HIV-1 genomes from individuals on long-term ART, focusing on individuals whose reservoirs are ...[more]