Unknown

Dataset Information

0

Evolutionary dynamics of circular RNAs in primates.


ABSTRACT: Many primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate evolution, we identify that within 3 million years circRNA expression profiles diverged such that they are more related to species identity than organ type. However, our analysis also revealed a subset of circRNAs with conserved neural expression across tens of millions of years of evolution. By comparing to species-specific circRNAs, we identified that the downstream intron of the conserved circRNAs display a dramatic lengthening during evolution due to the insertion of novel retrotransposons. Our work provides comparative analyses of the mechanisms promoting circRNAs to generate increased transcriptomic complexity in primates.

SUBMITTER: Santos-Rodriguez G 

PROVIDER: S-EPMC8516421 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7073761 | biostudies-literature
| S-EPMC6140489 | biostudies-literature
| S-EPMC9861842 | biostudies-literature
| S-EPMC3318445 | biostudies-literature
| S-EPMC7535116 | biostudies-literature
| S-EPMC8836038 | biostudies-literature
| S-EPMC7407480 | biostudies-literature
| S-EPMC3975061 | biostudies-literature
| S-EPMC6546045 | biostudies-literature
| S-EPMC5565156 | biostudies-other