Dataset Information

Vitamin B₁₂ impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.

ABSTRACT: Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective treatment. Diet, as a modifiable risk factor for AD, could potentially be targeted to slow disease onset and progression. However, complexity of the human diet and indirect effects of the microbiome make it challenging to identify protective nutrients. Multiple factors contribute to AD pathogenesis, including amyloid beta (Aβ) deposition, energy crisis, and oxidative stress. Here, we use Caenorhabditis elegans to define the impact of diet on Aβ proteotoxicity. We discover that dietary vitamin B₁₂ alleviates mitochondrial fragmentation, bioenergetic defects, and oxidative stress, delaying Aβ-induced paralysis without affecting Aβ accumulation. Vitamin B₁₂ has this protective effect by acting as a cofactor for methionine synthase, impacting the methionine/S-adenosylmethionine (SAMe) cycle. Vitamin B₁₂ supplementation of B₁₂-deficient adult Aβ animals is beneficial, demonstrating potential for vitamin B₁₂ as a therapy to target pathogenic features of AD triggered by proteotoxic stress.

SUBMITTER: Lam AB

PROVIDER: S-EPMC8522492 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Vitamin B<sub>12</sub> impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.

Lam Andy B AB Kervin Kirsten K Tanis Jessica E JE

Cell reports 20210901 13

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective treatment. Diet, as a modifiable risk factor for AD, could potentially be targeted to slow disease onset and progression. However, complexity of the human diet and indirect effects of the microbiome make it challenging to identify protective nutrients. Multiple factors contribute to AD pathogenesis, including amyloid beta (Aβ) deposition, energy crisis, and oxidative stress. Here, we use Caenorhabditis elegans ...[more]

PMID: 34592146

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Project description:Vitamin B12 is synthesized only by certain bacteria and archaeon, but not by plants. The synthesized vitamin B12 is transferred and accumulates in animal tissues, which can occur in certain plant and mushroom species through microbial interaction. In particular, the meat and milk of herbivorous ruminant animals (e.g. cattle and sheep) are good sources of vitamin B12 for humans. Ruminants acquire vitamin B12, which is considered an essential nutrient, through a symbiotic relationship with the bacteria present in their stomachs. In aquatic environments, most phytoplankton acquire vitamin B12 through a symbiotic relationship with bacteria, and they become food for larval fish and bivalves. Edible plants and mushrooms rarely contain a considerable amount of vitamin B12, mainly due to concomitant bacteria in soil and/or their aerial surfaces. Thus, humans acquire vitamin B12 formed by microbial interaction via mainly ruminants and fish (or shellfish) as food sources. In this review, up-to-date information on vitamin B12 sources and bioavailability are also discussed. Impact statement To prevent vitamin B12 (B12) deﬁciency in high-risk populations such as vegetarians and elderly subjects, it is necessary to identify foods that contain high levels of B12. B12 is synthesized by only certain bacteria and archaeon, but not by plants or animals. The synthesized B12 is transferred and accumulated in animal tissues, even in certain plant tissues via microbial interaction. Meats and milks of herbivorous ruminant animals are good sources of B12 for humans. Ruminants acquire the essential B12 through a symbiotic relationship with bacteria inside the body. Thus, we also depend on B12-producing bacteria located in ruminant stomachs. While edible plants and mushrooms rarely contain a considerable amount of B12, mainly due to concomitant bacteria in soil and/or their aerial surfaces. In this mini-review, we described up-to-date information on B12 sources and bioavailability with reference to the interaction of microbes as B12-producers.

Dataset Information

Vitamin B₁₂ impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.

Publications

Vitamin B<sub>12</sub> impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.

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Dataset Information

Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.

Publications

Vitamin B<sub>12</sub> impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Vitamin B₁₂ impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle.