Ontology highlight
ABSTRACT:
SUBMITTER: Marquez-Luna C
PROVIDER: S-EPMC8523709 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Márquez-Luna Carla C Gazal Steven S Loh Po-Ru PR Kim Samuel S SS Furlotte Nicholas N Auton Adam A Price Alkes L AL
Nature communications 20211018 1
Polygenic risk prediction is a widely investigated topic because of its promising clinical applications. Genetic variants in functional regions of the genome are enriched for complex trait heritability. Here, we introduce a method for polygenic prediction, LDpred-funct, that leverages trait-specific functional priors to increase prediction accuracy. We fit priors using the recently developed baseline-LD model, including coding, conserved, regulatory, and LD-related annotations. We analytically e ...[more]